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51.
52.
Ahamed Ibrahim Saravanan Natarajan 《Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids》2005,1733(1):67-75
This study describes the effect of substituting dietary linoleic acid (18:2 n-6) with α-linolenic acid (18:3 n-3) on sucrose-induced insulin resistance (IR). Wistar NIN male weanling rats were fed casein based diet containing 22 energy percent (en%) fat with ~6, 9 and 7 en% saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) respectively for 3 months. IR was induced by replacing starch (ST) with sucrose (SU). Blends of groundnut, palmolein, and linseed oil in different proportions furnished the following levels of 18:3 n-3 (g/100 g diet) and 18:2 n-6/18:3 n-3 ratios respectively: ST-220 (0.014, 220), SU-220 (0.014, 220), SU-50 (0.06, 50), SU-10 (0.27, 10) and SU-2 (1.1, 2). The results showed IR in the sucrose fed group (SU-220) as evidenced by increase in fasting plasma insulin and area under the curve (AUC) of insulin in response to oral glucose load. In SU-220, the increase in adipocyte plasma membrane cholesterol/phospholipid ratio was associated with a decrease in fluidity, insulin stimulated glucose transport, antilipolytic effect of insulin and increase in basal and norepinephrine stimulated lipolysis in adipocytes. In SU-50, sucrose induced alterations in adipocyte lipolysis and antilipolysis were normalized. However, in SU-2, partial corrections in plasma insulin, AUC of insulin and adipocyte insulin stimulated glucose transport were observed. Further, plasma triglycerides and cholesterol decreased in SU-2. In diaphragm phospholipids, the observed dose dependent increase in long chain (LC) n-3 PUFA was associated with a decrease in LC-n-6 PUFA but insulin stimulated glucose transport increased only in SU-2. Thus, this study shows that the substitution of one-third of dietary 18:2 n-6 with 18:3 n-3 (SU-2) results in lowered blood lipid levels and increases peripheral insulin sensitivity, possibly due to the resulting high LCn-3 PUFA levels in target tissues of insulin action. These findings suggest a role for 18:3 n-3 in the prevention of insulin resistant states. The current recommendation to increase 18:3 n-3 intake for reducing cardiovascular risk may also be beneficial for preventing IR in humans. 相似文献
53.
Aftab Ahamed Ajay Singh Owen P. Ward 《World journal of microbiology & biotechnology》2005,21(8-9):1577-1583
Summary While Aspergillus strains are also being considered as potential hosts for production of extracellular heterologous proteins, the proteases
produced by the host are highly problematic in that they typically modify and degrade the recombinant proteins. Culture-based
approaches for minimization of protease activity in culture supernatants of Aspergillus niger NRRL-3 included reduction or elimination of peptide nitrogen in the medium, preferential use of a defined salts medium rather
than a non-peptide nitrogen medium containing yeast-nitrogen base, supplementation of the medium with carboxymethylcellulose
and cultivation at pH 6.5 rather than 7.5. In general, increased proteolytic activity was observed after maximum biomass was
observed and biomass was declining suggesting the majority of protease activity was released by cell lysis. Carboxymethylcellulose
shifted mycelial morphology from pelleted to filamentous. Mycelium lysis in the centre of pellets, with resultant release
of intracellular proteases, would explain why filamentous cultures exhibited much lower proteolytic activity than pelleted
cultures. 相似文献
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56.
Wei Zhang Nick Bansback Annelies Boonen Adam Young Amitabh Singh Aslam H Anis 《Arthritis research & therapy》2010,12(5):R177
Introduction
The Work Productivity and Activity Impairment (WPAI) questionnaire is a well validated instrument to measure impairments in work and activities. However, its validation among patients with rheumatoid arthritis (RA) has not been well established. The present study's purpose is to evaluate the construct validity of the WPAI-general health version among RA patients and its ability to differentiate between RA patients with varying health status. 相似文献57.
58.
Length‐weight and length‐length relationships of three small indigenous fishes from the Payra River,southern Bangladesh 下载免费PDF全文
F. Ahamed N. Saha M. A. Nishat M. K. Biswas M. Sultana M. S. Khatun Z. F. Ahmed M. Y. Hossain J. Ohtomi 《Zeitschrift fur angewandte Ichthyologie》2018,34(3):777-779
Length‐weight relationships (LWRs) and length‐length relationships (LLRs) for three small indigenous fishes (Esomus danrica, Pachypterus atherinoides and Salmostoma bacaila) were reported from the Payra River, southern Bangladesh. Samples were collected using traditional fishing gear including cast net (mesh size ranges from 1.0 to 2.0 cm), seine net (mesh size ranges from 1.5 to 2.5 cm) and square lift net (mesh size ~ 1.0 cm) in August to September 2017. Allometric coefficient (b) values were 2.66 for E. danrica, 3.08 for P. atherinoides and 3.06 for S. bacaila. The LLRs were also highly significant with r2 ≥ .956. 相似文献
59.
Length–weight and length–length relationships of three ecologically important fishes caught from a wetland,northeastern Bangladesh 下载免费PDF全文
Length–weight relationships (LWRs) and length–length relationships (LLRs) of three ecologically important fishes (Aplocheilus panchax, Danio rerio and Esomus danrica) were reported from a wetland, northeastern Bangladesh (23 58 N, 89 38 E). Samples were collected monthly using traditional fishing gear including fine meshed (2.0 mm) push net and fine meshed (3.0–4.0 mm) surrounding net during January to December 2014. For each individual, total length (TL), fork length (FL) and standard length (SL) was measured to 0.1 cm, while body weight (BW) was measured to 0.01 g accuracy. Allometric coefficient (b) values were 3.10 for A. panchax, 3.38 for D. rerio and 3.52 for E. danrica. In addition, the LLRs were also highly significant with r2 ≥ 0.954. 相似文献
60.
Ferdous Ahamed Newton Saha Zoarder F. Ahmed Md. Yeamin Hossain Jun Ohtomi 《Zeitschrift fur angewandte Ichthyologie》2018,34(5):1169-1175
The gobioid fish Apocryptes bato (Hamilton, 1822) is a species of mudskipper found in Bangladesh, India, and Myanmar. The reproductive biology of A. bato including sex ratio, size at sexual maturity, breeding season, fecundity, and condition factor was studied in the Payra River, southern Bangladesh during May 2016 to April 2017. A total of 1,028 specimens (303 males and 725 females) were collected. The overall sex ratio was significantly different from the expected value of 1:1 (male: female = 1:2.39, χ2 = 173.23, p < 0.05). Size at sexual maturity was estimated as 4.9 cm standard length. Monthly variations in gonadosomatic index indicate that the main breeding season is from May to December. There was a significant positive correlation of body length and body weight with fecundity. Fulton's condition factor varied in both sexes and was attributed to variations in GSI with maturity. Breeding season was significantly associated with rainfall, but not air temperature. Our findings should improve management and conservation of this fish in the Payra River and surrounding ecosystems. 相似文献